POLARIS
The North Star to navigate the expanding universe of aging biomarkers
POLARIS unifies biomarker models, CpG‑level annotation, study knowledge,
and systematic benchmarking around a single guidance system.
methylCIPHER
LiveWhat biomarkers exist?
Biomarker Models
A catalog of aging-biomarker models: the algorithms, coefficients, and metadata behind each clock. Use it to find which biomarkers exist and inspect how each is defined.
TranslAGE
LiveWhich biomarkers perform well?
Systematic Benchmarking
Systematic benchmarking of aging biomarkers across stability, treatment response, phenotype associations, and risk prediction. Use it to compare how well biomarkers perform and which are best suited to a given task.
CpG Atlas
LiveWhat biology do these biomarkers capture?
CpG-level Annotation
CpG-level annotation of the biological, functional, and technical properties of methylation sites. Use it to understand what biology a biomarker's CpGs capture.
CpG Library
Coming soonWhat happened in the studies?
Study & Biomarker Knowledge
A searchable knowledge base of manuscripts covering datasets, biomarkers, and DNA-methylation biology. Use it to understand what a given study measured, in which cohorts, and what it reported. Built using MedViz for interactive visualization.
HarmonyAgent
Coming soonAutonomous Harmonization
The connective tissue of POLARIS. HarmonyAgent continually discovers, curates, and integrates new studies, biomarkers, and annotations across the platform so every other tool stays current. It is the hub connector rather than a question-answering component.
Interested in collaborating or contributing datasets? Reach out at a.higginschen@yale.edu.